We present a set of algorithms for automated simplification of symbolic constants of the form ∑iαixi with αi rational and xi complex. The included algorithms, called SimplifySum2 and implemented in Mathematica, remove redundant terms, attempt to make terms and the full expression real, and remove terms using repeated application of the multipair PSLQ integer relation detection algorithm. Also included are facilities for making substitutions according to user-specified identities. We illustrate this toolset by giving some real-world examples of its usage, including (...) one, for instance, where the tool reduced a symbolic expression of approximately 100 000 characters in size enough to enable manual manipulation to one with just four simple terms.2Available from https://github.com/alexkaiser/SimplifySum. (shrink)

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

According to history texts, philosophers searched for a unifying natural law whereby natural phenomena and numbers are related. More than 2300 years ago, Aristotle postulated that nature requires minimum energy. More than 220 years ago, Euler applied the minimum energy postulate. More than 200 years ago, Lagrange provided a mathematical “proof” of the postulate for conservative systems. The resulting Principle of Least Action served only to derive the differential equations of motion of a conservative system. Then, 170 years ago, Hamilton (...) presented what he claimed to be a “general method in dynamics.” Hamilton's resulting “Law of Varying Action” was supposed to apply to both conservative and non-conservative systems and was supposed to yield either the differential equations of motion or the integrals of those differential equations. However, no direct evaluation of the integrals of motion ever resulted from Hamilton's law of varying action. In 1975, a scant 29 years ago, following five years of controversy with engineer mechanicians, Dr. Wolfgang Yourgrau, Editor, Foundations of Physics, published my first paper based on Aristotle's postulate, without mathematical proof. That and subsequent papers present, through applications, a true “general method in dynamics.” In this essay, I present the mathematical proof that is missing from my 1975 and subsequent papers. Six fundamental integrals of analytical mechanics are derived from Aristotle's postulate. First, however, Hamilton must be revisited to show why his H function and his “force function” prevents the law of varying action from being the general method in dynamics that he claimed it to be. I have found that Hamilton’s Law of Varying Action (HLVA), as Hamilton presented it, cannot be applied to systems for which the force function is non-integrable. In 1972, Dr. B.E. Gatewood and Dr. D.P. Beres (then a graduate student) discovered that the end-point term associated with the principle of least action does not vanish. I named the new equation, “the general energy equation.” In 1973, because I was doing with it what Hamilton claimed could be done with HLVA, I simply assumed that this new equation was HLVA. I gave the new equation the misnomer HLVA. In 2001, I learned that I had made a grave mistake. I found that HLVA is at most a special case of the general energy equation. My interpretation of Aristotle's postulate permits one to by-pass the differential equations of motion completely for both conservative and non-conservative systems (no calculus of variations). (shrink)

Seneca ‘Rhetor’ was last critically edited by H. J. Müller in 1887; the editions of H. Bornecque and W. A. Edward lack an apparatus criticus, though the latter's notes give some attention to textual points. Whoever next addresses himself to the task can take heart from Eduard Norden : ‘der Text ist schwer korrupt, für Konjekturalkritik noch viel zu tun.’ It may be added that he will do a service by jettisoning a large proportion of what Konjekturalkritik has already produced-too (...) much of this nature in Müller's text and apparatus, to say nothing of later contributions, is merely depressing. (shrink)

Seneca ‘Rhetor’ was last critically edited by H. J. Müller in 1887; the editions of H. Bornecque and W. A. Edward lack an apparatus criticus, though the latter's notes give some attention to textual points. Whoever next addresses himself to the task can take heart from Eduard Norden : ‘der Text ist schwer korrupt, für Konjekturalkritik noch viel zu tun.’ It may be added that he will do a service by jettisoning a large proportion of what Konjekturalkritik has already produced-too (...) much of this nature in Müller's text and apparatus, to say nothing of later contributions, is merely depressing. (shrink)

Man (Islam); Islamic philosophy; Islamic ethics.

This is a study of the nature of time. In it, redeploying an argument first presented by McTaggart, the author argues that although time itself is real, tense is not. He accounts for the appearance of the reality of tense - our sense of the passage of time, and the fact that our experience occurs in the present - by showing how time is indispensable as a condition of action. Time itself is further analysed, and Dr Mellor gives answers to (...) most of the metaphysical questions it provokes, concerning the relation of time to space, the dissection of time, and its relation to change and causation. (shrink)

_Real Time II_ extends and evolves DH Mellor's classic exploration of the philosophy of time,_Real Time._ This new book answers such basic metaphysical questions about time as: how do past, present and future differ, how are time and space related, what is change, is time travel possible? His _Real Time_ dominated the philosophy of time for fifteen years. _Real TIme II_ will do the same for the next twenty. GET /english/edu/Studying_at_SU/History_of_Literature.html HTTP/1.0.

The Facts of Causation grapples with one of philosophy's most enduring issues. Causation is central to all of our lives. What we see and hear causes us to believe certain facts about the world. We need that information to know how to act and how to cause the effects we desire. D. H. Mellor, a leading scholar in the philosophy of science and metaphysics, offers a comprehensive theory of causation. Many questions about causation remain unsettled. In science, the indeterminism of (...) modern physics and genetics have made such questions considerably harder for philosophers to answer. While progress has been made, a complete account of the nature and cosequences of causation is long overdue. This major study provides that account. (shrink)

This book deals not so much with statistical methods as with the central concept of chance, or statistical probability, which statistical theories apply to nature.

Everything we do relies on causation. We eat and drink because this causes us to stay alive. Courts tell us who causes crimes, criminology tell us what causes people to commit them. D.H. Mellor shows us that to understand the world and our lives we must understand causation. _The Facts of Causation_, now available in paperback, is essential reading for students and for anyone interested in reading one of the ground-breaking theories in metaphysics. We cannot understand the world and our (...) place in it without understanding causation. Yet a complete account of the nature and implications of causation does not exist. D.H Mellor's new book is that account. (shrink)

Everything we do relies on causation. We eat and drink because this causes us to stay alive. Courts tell us who causes crimes, criminology tell us what causes people to commit them. D.H. Mellor shows us that to understand the world and our lives we must understand causation. _The Facts of Causation_, now available in paperback, is essential reading for students and for anyone interested in reading one of the ground-breaking theories in metaphysics. We cannot understand the world and our (...) place in it without understanding causation. Yet a complete account of the nature and implications of causation does not exist. D.H Mellor's new book is that account. (shrink)

This book: * assumes no mathematical background and keeps the technicalities to a minimum * explains the most important applications of probability theory to ...

Mellor's subject is singular causation between facts, expressed 'E because C'. His central requirement for causation is that the chance that E if C be greater than the chance that E if $\sim \text{C}\colon \ ch_{\text{C}}>ch_{\sim \text{C}}$. The book is as much about chance as it is about causation. I show that his way of distinguishing ch C from the traditional notion of conditional chance leaves him with a problem about the existence of ch Q when Q is false ; (...) and also that any notion of chance which conforms to the standard calculus has wider application than the causal instances to which Mellor's notion is restricted. Other topics discussed may be gleaned from the headings below. (shrink)

_Probability: A Philosophical Introduction_ introduces and explains the principal concepts and applications of probability. It is intended for philosophers and others who want to understand probability as we all apply it in our working and everyday lives. The book is not a course in mathematical probability, of which it uses only the simplest results, and avoids all needless technicality. The role of probability in modern theories of knowledge, inference, induction, causation, laws of nature, action and decision-making makes an understanding of (...) it especially important to philosophers and students of philosophy, to whom this book will be invaluable both as a textbook and a work of reference. In this book D. H. Mellor discusses the three basic kinds of probability – physical, epistemic, and subjective – and introduces and assesses the main theories and interpretations of them. The topics and concepts covered include: * chance * frequency * possibility * propensity * credence * confirmation * Bayesianism. _Probability: A Philosophical Introduction_ is essential reading for all philosophy students and others who encounter or need to apply ideas of probability. (shrink)

The paper looks at the semantics and ontology of dispositions in the light of recent work on the subject. Objections to the simple conditionals apparently entailed by disposition statements are met by replacing them with so-called 'reduction sentences' and some implications of this are explored. The usual distinction between categorical and dispositional properties is criticised and the relation between dispositions and their bases examined. Applying this discussion to two typical cases leads to the conclusion that fragility is not a real (...) property and that, while both temperature and its bases are, this does not generate any problem of overdetermination. (shrink)